Mitochondrial-derived peptide encoded in the 12S rRNA gene. A groundbreaking research compound for metabolic and longevity science. For laboratory research purposes only.
ORDER NOW →Single 10mg vial. Standard research quantity for mitochondrial pathway studies. HPLC verified, COA included.
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| Specification | Details |
|---|---|
| Common Name | MOTS-c (Mitochondrial ORF of the 12S rRNA type-c) |
| Class | Mitochondrial-Derived Peptide (MDP) |
| Origin | Encoded in mitochondrial 12S rRNA gene |
| Amino Acids | 16-amino acid peptide |
| Mechanism | AMPK Pathway Activation / Mitochondrial-Nuclear Signaling |
| Purity | ≥99% (HPLC Verified) |
| Form | Lyophilized Powder |
| Storage | -20°C, protect from light |
| Available Sizes | 10mg, 50mg |
| Certificate | COA Included |
MOTS-c is a 16-amino acid peptide encoded within the mitochondrial 12S rRNA gene — making it one of the few known peptides of mitochondrial origin. Research has shown it plays roles in metabolic homeostasis, insulin sensitivity, and mitochondria-to-nucleus retrograde signaling, representing a novel class of signaling molecules with broad research implications.
Laboratory research on MOTS-c has primarily focused on its activation of the AMPK pathway, its effects on glucose metabolism and insulin sensitivity in various tissue models, and its role as a mitochondrial stress-responsive signaling molecule. It is also being studied for its potential roles in aging and exercise physiology research.
AscendLabz guarantees a minimum 99% purity for all MOTS-c peptides, confirmed by HPLC analysis. A Certificate of Analysis is provided with every order, giving researchers full documentation of peptide identity and purity for reporting and compliance purposes.
RESEARCH USE ONLY: All products sold by AscendLabz are strictly for laboratory research purposes only. Not for human consumption. Not for veterinary use. Must be handled by qualified research professionals in a controlled laboratory environment.
MOTS-c is a 16-amino-acid peptide encoded by the mitochondrial 12S rRNA region studied as part of the mitochondrial-derived peptide category. It is investigated in pre-clinical and in-vitro research models for its activity on AMPK activation, mitochondrial metabolism, and folate-cycle pathways studied in vitro. The compound is supplied as a lyophilized powder of ≥99% HPLC-verified purity and is intended exclusively for laboratory research use under qualified scientific supervision.
AscendLabz MOTS-c is sourced from cGMP-aligned synthesis facilities and validated for identity, purity, and counter-ion content prior to release. Each lot is independently tested by HPLC, and a Certificate of Analysis (COA) detailing peak area, retention time, and batch number is provided with every order. This level of documentation is intended to support reproducible research and clear chain-of-custody record-keeping in academic and independent laboratory environments.
For research workflows, MOTS-c is most commonly characterized in cell-culture and isolated-tissue models where investigators examine AMPK activation and mitochondrial signaling alongside complementary compounds in the mitochondrial-derived research peptides class. Reference standards and dose-response controls should be established by each laboratory prior to experimental use, and all material should be handled by trained personnel using appropriate personal protective equipment.
Storage: Lyophilized MOTS-c is stable at -20°C protected from light. Reconstituted peptide should be refrigerated at 2-8°C and used within 14 days. Lyophilized peptides should be kept in original sealed packaging until use to prevent moisture uptake.
Reconstitution: Bring the lyophilized vial to room temperature before opening. Reconstitute with bacteriostatic water by injecting solvent down the inner wall of the vial; do not direct the stream onto the lyophilized cake. Gently swirl — do not vortex or shake — until fully dissolved. Allow 5-10 minutes for complete solvation.
Handling: Use sterile technique throughout. Wipe vial septa with isopropyl alcohol before each draw. Document reconstitution date, solvent volume, and resulting concentration on the vial label for traceability.
Every batch of MOTS-c is analyzed by reverse-phase HPLC and confirmed to be ≥99% pure. Mass spectrometry confirms molecular identity, and counter-ion / residual-solvent panels are performed where applicable. The full Certificate of Analysis ships with each order and is also archived by lot number.
No. MOTS-c is supplied strictly for in-vitro laboratory research and is not approved by the FDA, EMA, or any regulatory authority for human or veterinary therapeutic use. It must not be administered to humans or animals. By purchasing, you confirm you are a qualified researcher and the material will be used only in a controlled laboratory setting.
All orders ship from the USA via tracked courier within 24-48 hours of payment confirmation. Domestic delivery typically arrives within 2-5 business days in discreet, temperature-stable packaging. Tracking is provided by email at the time of dispatch.
AscendLabz prices MOTS-c competitively while maintaining ≥99% HPLC-verified purity and a full COA. Bulk-vial bundles offer additional savings for laboratories ordering multi-month research supply. Pricing is reviewed monthly to remain among the most affordable verified-purity sources in the United States.
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Yes. Most laboratories order MOTS-c together with complementary compounds from the mitochondrial-derived research peptides category. Combined orders ship together with a single COA package and qualify for bulk-tier pricing. See the related compounds section below for commonly paired research peptides.
Researchers ordering MOTS-c frequently study it alongside these related compounds:
SS-31 · NAD+ · 5-Amino-1MQ · Epitalon